There are several ways to remove a Twitter follower. You can block them, mute them, or report them. Blocking someone prevents them from following you, seeing your tweets, or sending you direct messages. Muting someone prevents their tweets from appearing in your timeline, but they can still follow you and send you direct messages. Reporting someone allows Twitter to investigate their behavior and take action if necessary.
The best way to get rid of a Twitter follower depends on the situation. If someone is harassing you or sending you unwanted messages, blocking them is the best option. If you simply don’t want to see someone’s tweets, muting them is a good choice. Reporting someone is only necessary if they are violating Twitter’s terms of service.